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Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission
Xiaohong Shi, Xuefei Wang, Xixi Xu, Yongliang Feng, Shuzhen Li, Shuying Feng, Bo Wang, Suping Wang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 548-553 doi: 10.1007/s11684-017-0597-5
Keywords: PBMC HBV cccDNA HBV rcDNA HBV intrauterine transmission
Current recommendations of managing HBV infection in preconception or pregnancy
James S. Park,Calvin Pan
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 158-165 doi: 10.1007/s11684-014-0340-4
Hepatitis B remains a leading cause of cirrhosis, hepatocellular carcinoma and liver transplantation worldwide. Management of chronic hepatitis B during pregnancy is challenging. Transmission of hepatitis B to infants still occurs perinatally although immunoprophylaxis is widely available for infants born to mothers with chronic hepatitis B infection. The emerging data suggest that initiation of antiviral therapy in the beginning of the third trimester in highly viremic mothers can prevent immunoprophylaxis failure in their infants. The available drug safety data show that lamivudine, telbivudine and tenofovir are generally safe to be used during the pregnancy. In order to minimize the fetal exposure to the antiviral medication, antiviral therapy during the pregnancy should be limited to a selected group of patients with cirrhosis, high hepatitis B viral load, or prior history immunoprophylaxis failure. An elective Caesarean section may reduce the risk of perinatal transmission. For those females planning for pregnancy or in early stage of pregnancy, communication and follow-up among obstetrician, gastroenterologist, and primary care physician are important. In this article, we will review the features of hepatitis B infection before, during and after the pregnancy; the risk factors that increase mother-to-child transmission; safety data on antiviral drug use during pregnancy; and the potential role of Caesarean section in selected cases.
Keywords: antiviral therapy Caesarean section cirrhosis hepatitis B immunoprophylaxis mother-to-child transmission pregnancy prevention
New perspective on the natural course of chronic HBV infection
Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 129-134 doi: 10.1007/s11684-014-0339-x
Chronic hepatitis B virus (HBV) infection is a significant threat to public health and an enormousMechanisms responsible for chronic HBV infection remain poorly understood.Natural course of chronic HBV infection is conventionally viewed as an uninterrupted process that iswith assumed host responses to HBV infection.and reinfection, and such cycles prolong the chronic HBV infection course.
Keywords: hepatitis B virus chronic HBV infection natural course hepatitis B seroconversion
A Resilience Approach for Diagnosing and Predicting HBV-Related Diseases based on Blood Tests Article
Gege Hou,Yunru Chen,Xiaojing Liu,Dong Zhang,Zhimin Geng,Shubin Si
Engineering 2024, Volume 32, Issue 1, Pages 174-185 doi: 10.1016/j.eng.2023.06.013
Chronic hepatitis B virus (HBV) infection, which threatens global publicExaminations for liver diseases related to chronic HBV infection—including laboratory tests, ultrasoundsestablish an economical and effective diagnosis method in order to streamline the medical process for HBV-related
Keywords: HBV-related diseases Functional resilience Improve medical resource utilization Critical states Network
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 502-508 doi: 10.1007/s11684-017-0590-z
Keywords: chronic hepatitis B serum HBV RNA nucleos(t)ide analogs virological response para-functional cure
Eliminating mother-to-child transmission of HBV: progress and challenges in China
Wenzhan Jing, Jue Liu, Min Liu
Frontiers of Medicine 2020, Volume 14, Issue 1, Pages 21-29 doi: 10.1007/s11684-020-0744-2
Keywords: hepatitis B virus mother-to-child transmission progress challenge
Current hepatitis B treatment guidelines and future research directions
Jonathan Skupsky,Ke-Qin Hu
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 145-157 doi: 10.1007/s11684-014-0335-1
Hepatitis B virus (HBV) infection causes a tremendous clinical burden across the world with more thanhalf a million people dying annually from HBV related disease.Significant advances have been made in HBV treatment in the past decade and several guidelines have beenAlthough these recommendations have been valuable to help optimize HBV treatment, there is discordancein treatment criteria and many patients infected with HBV may fall outside of these recommendations.
Keywords: chronic hepatitis B HBV treatment guidelines APASL guidelines EASL guidelines AASLD guidelines
Current advances in the elimination of hepatitis B in China by 2030
Shuye Zhang, Fusheng Wang, Zheng Zhang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 490-501 doi: 10.1007/s11684-017-0598-4
With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leadingOver the last two decades, China has made great progress on the prevention of HBV transmission throughAvailable anti-HBV therapy is efficacious in suppressing HBV replication; however, it fails to completelyimprove the efficacy, several trials have been recently conducted in China to optimize the current anti-HBVReports also indicate that coinfections of HBV with other hepatotropic viruses and human immunodeficiency
Keywords: HBV CHB biomarker functional cure coinfection
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 399-411 doi: 10.1007/s11684-010-0170-y
Keywords: hepatocellular carcinoma hepatitis B virus X protein β -catenin cell adhesion E-cadherin transcriptional activation
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 90-95 doi: 10.1007/s11684-010-0021-x
Keywords: cyclooxygenase-2 gene single nucleotide polymorphisms susceptibility primary hepatocellular carcinoma hepatitis B virus infection
Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 217-226 doi: 10.1007/s11684-014-0326-2
Keywords: hepatocellular carcinoma (HCC) interaction miRNA-122-binding site IL-1A rs3783553 hepatitis B virus (HBV
Title Author Date Type Operation
Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission
Xiaohong Shi, Xuefei Wang, Xixi Xu, Yongliang Feng, Shuzhen Li, Shuying Feng, Bo Wang, Suping Wang
Journal Article
Current recommendations of managing HBV infection in preconception or pregnancy
James S. Park,Calvin Pan
Journal Article
New perspective on the natural course of chronic HBV infection
Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan
Journal Article
A Resilience Approach for Diagnosing and Predicting HBV-Related Diseases based on Blood Tests
Gege Hou,Yunru Chen,Xiaojing Liu,Dong Zhang,Zhimin Geng,Shubin Si
Journal Article
Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide
Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia
Journal Article
Eliminating mother-to-child transmission of HBV: progress and challenges in China
Wenzhan Jing, Jue Liu, Min Liu
Journal Article
Current hepatitis B treatment guidelines and future research directions
Jonathan Skupsky,Ke-Qin Hu
Journal Article
Current advances in the elimination of hepatitis B in China by 2030
Shuye Zhang, Fusheng Wang, Zheng Zhang
Journal Article
Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
Journal Article
Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-control
Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,
Journal Article